3, 4 Due to concerns over gastrointestinal toxicity, selective COX-2 inhibitors were developed that aimed to eliminate the COX-1-associated adverse effects on the gastric mucosa. 2 In the United States, over a million prescriptions are written for NSAIDs every year. They are among the most commonly purchased or prescribed drugs around the world, used by approximately 30 million people daily. NSAIDs are a widely available and frequently prescribed class of analgesics. Here, we discuss the evidence with regard to an association between selective and nonselective NSAIDs and stroke risk, along with the potential pathophysiologic mechanisms and the targets for future study. Stroke comprises another important subset of cardiovascular events. Much publicity has focused on the adverse cardiovascular effects related to this class of medications however, the predominant focus has been primarily on the risk of MI.
NSAIDs are a class of analgesics widely available both in prescription form and over the counter. 1 Another nontraditional factor that may contribute to stroke risk is the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The traditional risk factors are similar to those for myocardial infarction (MI) and include hypertension, diabetes, smoking, and dyslipidemia. 1 As the burden of stroke remains high, it is important to identify the factors that may contribute to an increase in risk, especially those factors that may be avoidable. Each year, nearly 800,000 new or recurrent stroke events occur and account for approximately one out of every 18 deaths in the United States. Stroke remains a common cause of morbidity and mortality within the general population.
0 kommentar(er)
